Clinical effectiveness of probiotic organisms is dependent on many variables. Identification and selection of appropriate, documented probiotic species as well as maintenance of maximum viability throughout all stages of handling is central to expression of the full potential of beneficial flora. Klaire Labs’ probiotic quality assurance commitment consists of an aggressive, independent testing program that monitors and ensures the identity, activity, and hypoallergenicity of our finished products.

Genetic Identification by DNA Ribotyping
Ribotyping is a highly reproducible, precise diagnostic genetic fingerprint that identifies and classifies bacteria based upon differences in ribosomal RNA. This method establishes the authenticity of probiotic lactic acid bacteria (LAB) by comparing them to strains documented in the literature to possess a specific genetic makeup or pattern. LAB strains used in Klaire Labs’ probiotic formulations have undergone ribotyping to validate the specific genetic pattern in comparison to established, documented strains.

Analytical Testing for Casein/Dairy Proteins
Ensuring the absence of dairy proteins in probiotic supplements is a difficult task, as almost all commonly available probiotic materials are grown on dairy-containing media. Klaire Labs’ probiotic bacteria are specially cultured on a dairy-free growth media to help ensure maximum tolerance. Verifying lack of dairy proteins in probiotics is just as problematic, as common test methods are not sufficiently sensitive to accurately measure trace amounts of dairy. To overcome this uncertainty, Klaire Labs’ probiotics have been analyzed using Neogen® Veritox testing, a highly sensitive technique that detects levels as low as 0.00025% (<2.5 ppm) of dairy/casein. Other methods commonly employed in the industry have higher detection levels of 0.1% (1,000 ppm) and may inaccurately report absence of dairy even though it is present.

Raw Material Quarantine and Analysis
Probiotic organisms can suffer loss of potency during storage and transport. Thus, all incoming probiotic raw materials are quarantined upon arrival and tested to verify the activity and purity stated by our suppliers. Materials that do not meet specifications are rejected. Materials that pass this certification procedure are maintained under temperature- and humidity-controlled conditions at all times to ensure maximum viability of the probiotic microorganisms.

Independent Finished Product Testing
To ensure that manufacturing and packaging processes do not adversely affect potency, all KIaire Labs finished probiotic products are independently tested prior to release. Probiotic enumeration, microbial content, and coliform content are evaluated on each batch to ensure quality of the final product.

Probiotics

Why Klaire Probiotics?

Functions of Probiotic Species

Probiotic Certification Program

Intactic Acid Stable Technology

Cross-Reference Guide